张志荣 讲师

电子邮箱:go7446@qq.com

-基本信息

名字: 张志荣 Chih-Jung Chang

电子邮件: chan.chih.jung@gmail.com

go7446@qq.com

-学历

中国台湾 中山医学大学营养学学士 (2003/9~2007/6)

中国台湾 长庚大学医学生物技术所硕士 (2007/9~2009/6)

中国台湾 长庚大学生物医学所微生物暨免疫组博士 (2010/9~2015/5)

-经历

中国台湾 长庚大学分子暨临床免疫中心 博士后研究员 (2015/08~2017/08)

中国台湾 长庚大学微生物相研究中心 助理研究员 (2017/09~2019/02)

中国福建 厦门长庚医院中心实验室 副研究员(2019/06~至今)

中国福建 厦门长庚医院精准医学检验室主任 (2022/09~至今)

中国福建 欧冠体育app官网 特聘副教授 (2021/10~至今)

中国福建 厦门市医学会变态反应分会委员(2021/12~至今)

-获得奖项

中国台湾 微生物学会 严智钟奖学金 优秀论文奖 (2015)

中国台湾 中国化学制药股份有限公司王民宁先生纪念基金会 最佳论文大奖 (2015)

中国台湾牛樟芝国际研讨会 参奖 (2016)

福建省高層次人才C類 (2022)

-国际学术会议重要报告

Chih-Jung Chan, Hsin-Chih Lai. Immuno-modulatory effect of Ganoderma Lucidum on Natural killer cells. Lorne Infection & Immunity Conference, Australia 2012

Chih-Jung Chan, Hsin-Chih Lai .Ganoderma Lucidum water extract activates Natural Killer cells cytotoxicity activity through NKG2D and NCRs signaling pathways. Metabolic Control of Inflammation and Immunity, USA, 2013

Chih-Jung Chang, Chuan-Sheng Lin, Hsin-Chih Lai. Ganoderma lucidum alters intestinal microbiota and involves amelioration of HFD-induced obesity mice. Exploiting and Understanding Chemical Biotransformations in the Human Microbiome (D1). April 1, 2014 - April 6, 2014 - Big Sky Resort - Big Sky, Montana, USA

Chih-Jung Chang, Hsin-Chih Lai. Effect of traditional chinese medicine, Antrodia cinnamomea, on high fat diet induced obesity. C1: Gut Microbiota Modulation of Host Physiology: The Search for Mechanism. March 1, 2015­March 6, 2015, Keystone Resort, Keystone, Colorado, USA.

Chih-Jung Chang, Chia-Chen Lu, Hsin-Chih Lai. Antrodia cinnamomea enhances Akkermansia muciniphila and ameliorates high-fat-diet induced obesity in mice. IMCD 2017 Conference, FIJI.

-论文发表

1. Lai HC, Chang CJ, Yang CH, Hsu YJ, Chen CC, Lin CS, Tsai YH, Huang TT, Ojcius DM, Tsai YH, Lu CC*. Activation of NK cell cytotoxicity by the natural compound 2,3-butanediol. Journal of Leukocyte Biology 2012 Oct;92 (4):807-14. (SCI, IF=6.011)

2. Chang CJ, Chen YY, Lu CC, Lin CS, Martel J, Tsai SH, Ko YF, Huang TT, Ojcius DM, Young JD*, Lai HC*. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immunity. 2014 Apr; 20(3):301-11 (SCI, IF=2.951, First author)

3. Huang TT, Lai HC, Chen YB, Chen LG, Wu YH, Ko YF, Lu CC, Chang CJ, Wu CY, Martel J, Ojcius DM, Chong KY*, Young JD*. Cis-Resveratrol produces anti-inflammatory effects by inhibiting canonical and non-canonical inflammasomes in macrophage. Innate Immunity. 2014;20:735-50. (SCI, IF=2.951)

4. Chun-Hung Yang, Hui-Ling Wang, Yi-Sheng Lin, K.P. Shravan Kumar, Hung-Chi Lin, Chih-Jung Chang, Chia-Chen Lu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, Yu-Sun Chang, John D. Young* and Hsin-Chih Lai*. Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma. Plos one 2014 Jun 23;9(6):e99412 (SCI, IF=3.752)

5. Chia-Chen Lu, Ting Shu Wu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Ju-Hsin Chia, Tsu-Lan Wu, Tsung-Teng Huang, Jan Martel, David Ojcius, John D. Young* and Hsin-Chih Lai*. Direct perforin-dependent killing of mycobacteria by NK cells. Journal of Leukocyte Biology 2014 Dec;96(6):1119-29 (SCI, IF=6.011)

6. Chuan-Sheng Lin#, Chih-Jung Chang#, Chia-Chen Lu, Jan Martel, David M. Ojcius, Yun-Fei Ko, John D.Young*, Hsin-Chih Lai*. Impact of the gut microbiota, prebiotics, and probiotics on human health and disease. Biomedical Journal 2014 Sep-Oct; 37(5):259-68 (SCI, IF=7.892, Co-first author)

7. Chih-Jung Chang, Gut microbiota, Obesity and Traditional Chinese Medicine. Journal of Biomedical & Laboratory Sciences, 2014.

8. Chih-Jung Chang#, Chuan-Sheng Lin#, Chia-Chen Lu, Jan Martel, Yun-Fei Ko, David M. Ojcius, Shun-Fu Tseng, Tsung-Ru Wu, Yi-Yuan Margaret Chen, John D. Young* & Hsin-Chih Lai*. Ganoderma lucidum mycelium modulates the gut microbiota and reduces obesity in mice. Nature Communications. 2015 Jun 23;6:7489 (SCI, IF=17.694, first author)

9. Chia-Chen Lu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Jan Martel, David M Ojcius, Yun-Fei Ko, Hsin-Chih Lai*, John D Young*. Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity. Innate Immunity. 2016 Oct;22(7):522-33.( SCI, IF=2.951)

10. Chuan-Sheng Lin, Yu-Huan Tsai, Chih-Jung Chang, Shun-Fu Tseng, Tsung-Ru Wu, Chia-Chen Lu, Ting-Shu Wu, Jang-Jih Lu, Jim-Tong Horng, Jan Martel, David M. Ojcius, Hsin-Chih Lai& John D. Young*. An iron detection system determines bacterial swarming initiation and biofilm formation. Scientific Reports 2016 Nov 15;6:36747. (SCI, IF=4.996)

11. Chuan-Sheng Lin, Chih-Jung Chang, Jan Martel, David M. Ojcius, Wei-Fan Lai, Chia-Chen Lu, Yun-Fei Ko, John D.Young*, Hsin-Chih Lai. Lipopolysaccharide: friend of foe? Journal of Biomedical & Laboratory Sciences. 2016;28:121

12. Jan Martel, David M. Ojcius, Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Yun-Fei Ko, Shun-Fu Tseng, Hsin-Chih Lai* & John D. Young*. Anti-obesogenic and antidiabetic effects of plants and mushrooms. Nature Review Endocrinology. 2017 Mar;13(3):149-160. (SCI, IF=47.564)

13. Wei CF, Tsai YH, Tsai SH, Lin CS, Chang CJ, Lu CC, Huang HC, Lai HC. Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development. Biochem Biophys Res Commun. 2017 Jul 15;489(1):70-75 (SCI, IF=3.322)

14. Martel J, Ko YF, Ojcius DM, Lu CC, Chang CJ, Lin CS, Lai HC, Young JD. Immunomodulatory Properties of Plants and Mushrooms. Trends Pharmacol Sci. 2017 Nov;38(11):967-981 (SCI, IF=17.638)

15. Schachter J, Martel J, Lin CS, Chang CJ, Wu TR, Lu CC, Ko YF, Lai HC, Ojcius DM, Young JD. Effects of obesity on depression: A role for inflammation and the gut microbiota. Brain Behav Immun. 2017 Sep 6. pii: S0889-1591(17)30415-4 (SCI, IF=19.227)

16. Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, Young JD. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obes (Lond). 2018 Feb;42(2):231-243 (SCI, IF=5.551, First author)

17. Lai HC, Chang CJ, Lin CS, Wu TR, Hsu YJ, Wu TS, Lu JJ, Martel J, Ojcius DM, Ku CL, Young JD, Lu CC. NK Cell-Derived IFN-γ Protects against Nontuberculous Mycobacterial Lung Infection. J Immunol. 2018 Sep 1;201(5):1478-1490. (SCI, IF=5.426)

18. Wu TR#, Lin CS#, Chang CJ#, Lin TL, Martel J, Ko YF, Ojcius DM, Lu CC, Young JD, Lai HC. Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis. Gut. 2019 Feb;68(2):248-262 (SCI, IF=31.793, co-first author)

19. Tsai YL, Lin TL, Chang CJ, Wu TR, Lai WF, Lu CC, Lai HC. Probiotics, prebiotics and amelioration of diseases. J Biomed Sci. 2019 Jan 4;26(1):3 (SCI, IF=12.771, co-first author)

20. Martel J, Ojcius DM, Ko YF, Chang CJ, Young JD. Antiaging effects of bioactive molecules isolated from plants and fungi. Med Res Rev. 2019 Sep;39(5):1515-1552 (SCI, IF=12.338)

21. Chih-Jung Chang, Tzu-Lung Lin, Yu-Ling Tsai, Tsung-Ru Wu, Wei-Fan Lai, Chia-Chen Lu and Hsin-Chih Lai. Next generation probiotics in disease amelioration. J Food Drug Anal. 2019 Jul;27(3):615-622.(SCI, IF=6.157, First author)

22. Yu-Ling Tsai, Wen-Chiuan Tsai, ZhuQing, Chih-Jung Chang.

Dichotomous effects of microbial membrane vesicles on the regulation of immunity. Medicine in Microecology, 2020 March, Corresponding author)

23. Chang CJ, Chen CB, Hung SI, Ji C, Chung WH. Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions. Front Pharmacol 2020 Jul 2;11:969 (SCI, IF=5.988, First author)

24. Hsin-Chih Lai, Tzu-Lung Lin, Ting-Wen Chen, Yu-Lun Kuo, Chih-Jung Chang Tsung-Ru Wu, Ching-Chung Shu, Ying-Huang Tsai, Simon Swift, Chia-Chen Lu. Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide. Gut. 2022;71(2):309-321 (SCI, IF=31.793)

25. Yu-Chieh Weng, Wei-Ting Chen, Jung-Chieh Lee, Yung-Ning Huang, Chih-Kai Yang, Hui-Shan Hsieh, Chih-Jung Chang, Yang-Bor Lu. Intestinal fatty acid-binding protein is a biomarker for diagnosis of biliary tract infection. JGH Open. 2021;5:1160 (SCI, IF=1.66, co-Corresponding author)

26. Chang CJ, Wang H, Zhang J, Zou Y, Zhang Y, Chen J, Chen CB, Chung WH, Ji C. Distinct proteomic profiling of plasma extracellular vesicles from moderate-to-severe atopic dermatitis patients. Clin Cosmet Investig Dermatol. 2021;14:1033 (SCI, IF=2.765, First author)

27. Chih-Jung Chang, Jing Zhang, Yu-Ling Tsai, Chun-Bing Chen, Chun-Wei Lu, Yu-Ping Huo, Huey-Ming Liou, Chao Ji *, Wen-Hung Chung *. Compositional Features of Distinct Microbiota Base on Serum Extracellular Vesicle Metagenomics Analysis in Moderate to Severe Psoriasis Patients. Cells. 2021;10:2349 (SCI, IF=7.66, First author)

28. Tsai-Yeh, Chiang, Yu-Ru Yang, Ming-Ying Zhuo, Feng Yang, Ying-Fei Zhang, Chia-Hsiang Fu, Ta-Jen Lee, Wen-Hung Chung, Liang Chen, Chih-Jung Chang. Microbiome profiling of nasal extracellular vesicles in patients with allergic rhinitis. World Allergy Organization Journal 2022; 15:100674 (SCI, IF=5.6, Corresponding author)

29. Wang CW, Chi MH, Tsai TF, Yu KH, Kao HW, Chen HC, Chen CB, Lu CW, Chen WT, Chang YC, Chang CJ, Chang YT, Jan Wu YJ, Chang CJ, Huang YH, Ng CY, Huang PW, Lin YJ, Hui RC, Chung WH. Implementation of NUDT15 genotyping to prevent Azathioprine-induced leukopenia for patients with autoimmune disorders in Chinese population. Clin Pharmacol Ther

2022 Jul 22. doi: 10.1002/cpt.2716. (SCI, IF=6.903)

30. Lu CW, Pang JS, Ko YS, Chang CJ, Wang CW, Chen WT, Chen CB, Hui RC, Hung SI, Lu LY, Lu KL, Wang CL, Wu CE, Hsu PC, Fang YF, Li SH, Ko HW, Tseng LC, Shih FY, Chen MJ, Chung WH. Zinc deficiency associated with cutaneous toxicities induced by epidermal growth factor receptor tyrosine kinase inhibitor therapy in patients with lung adenocarcinoma. J Eur Acad Dermatol Venereol. 2022 Nov 10. doi: 10.1111/jdv.18703 (SCI, IF=9.228)

31. Wang CW, Lin WC, Chen WT, Chen CB, Lu CW, Hou HH, Hui RC, Wu J, Chang CJ, Chang YC, Chung WH; Taiwan Severe Cutaneous Adverse Reaction Consortium. Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population. Front Pharmacol. 2022 Nov 25;13:954596 (SCI, IF=5.988)

-专利申请

美国:

Method to prepare Ganoderma lucidum polysaccharides possessing anti-obesity properties and uses thereof

Method to prepare Ganoderma lucidum polysaccharides possessing insulin-sensitizing properties and applications thereof

Method to prepare Ganoderma lucidum polysaccharides possessing protective activities on fatty liver disease

Method to prepare hirsutella sinensis polysaccharides possessing anti-obesity properties and uses thereof

Method to prepare Hirsutella sinensis polysaccharides possessing insulin-sensitizing properties and applications thereof

Method to prepare Hirsutella sinensis polysaccharides possessing protective activities on fatty liver disease

Method to reduce body weight, fat accumulation and adipocyte size using Parabacteroides goldsteinii

Method to reduce insulin resistance and improve glucose tolerance using Parabacteroides goldsteinii

Method to treat fatty liver disease using Parabacteroides goldsteinii

台湾:

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大陆:

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