研究生教学

-基本信息

-研究方向

方向一：功能基因组学，基于CRISPR/Cas13等反向遗传学技术和慢病毒插入突变文库筛选等正向遗传学方法，结合高通量测序和生物信息学分析，对基因组中的长链非编码RNA及参与抗癌药物耐药作用的新基因和新转录本进行功能鉴定。

方向二：基因组学新方法新技术开发，通过基因组特征性序列标记和捕获，结合高通量测序技术，开发新的基因组学研究方法和技术，主要研究对象包括全基因组范围内的DNA损伤（如单链和双链DNA断裂）、基因组中的单链DNA区域，以及线粒体DNA复制起点等。

-教育经历

2014/10-2017/09，北海道大学，博士

2010/09-2013/06，华南理工大学，硕士

2006/09-2010/06，北京林业大学，学士

-科研与学术工作经历

2017/12-今，华侨大学，欧冠体育app官网，讲师

-课程教学

1、 分子肿瘤学（中文及全英文课程，本科生课程）

2、 工业及药物生物技术（全英文课程，本科生课程）

3、 生物医学工程进展（硕士生课程）

4、 科技文献写作专题（硕士生课程）

-参与或主持科研项目

1、国家自然科学基金，青年科学基金项目，24万元，主持

2、福建省自然科学基金面上项目，10万元，主持

3、华侨大学中青年教师科技创新资助计划，40万元，主持

4、华侨大学高层次人才科研启动费项目，12万元，主持

5、福建省自然科学基金重点项目，30万元，参与

6、国家自然科学基金，面上项目，58万元，参与

-发表文章

1. Dongyang Xu, Lu Tang, Philipp Kapranov*, Complexities of mammalian transcriptome revealed by targeted RNA enrichment techniques. Trends in Genetics, 2023, 39: 329-333.

2. Fan Gao, Ye Cai, Philipp Kapranov*, Dongyang Xu*, Reverse-genetics studies of lncRNAs—what we have learnt and paths forward, Genome Biology, 2020, 21: 93.

3. Huifen Cao^#, Dongyang Xu^#, Ye Cai^#, Xueer Han^#, Lu Tang, Fan Gao, Yao Qi, Dingding Cai, Huifang Wang, Maxim Ri, Denis Antonets, Yuri Vyatkin, Yue Chen, Xiang You, Fang Wang, Estelle Nicolas, Philipp Kapranov*, Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans, BMC Biology, 2021, 19: 108. (Co-first author)

4. Dongyang Xu, Yu Huang, Lingcong Luo, Lu Tang, Meng Lu, Huifen Cao, Fang Wang, Yong Diao, Liudmila Lyubchenko, Philipp Kapranov*, Genome-wide profiling of endogenous single-stranded DNA using the SSiNGLe-P1 method. International Journal of Molecular Sciences, 2023, 24, 12062.

5. Dongyang Xu^#, Lingcong Luo^#, Yu Huang, Meng Lu, Lu Tang, Yong Diao, Philipp Kapranov*, Dynamic patterns of mammalian mitochondrial DNA replication uncovered using SSiNGLe-5'ES. International Journal of Molecular Sciences, 2023, 24, 9711.

6. Dongyang Xu^#, Ye Cai^#, Lu Tang, Xueer Han, Fan Gao, Huifen Cao, Fei Qi, Philipp Kapranov*, A CRISPR/Cas13-based approach demonstrates biological relevance of vlinc class of long non-coding RNAs in anticancer drug response, Scientific Reports, 2020, 10: 1794.

7. Dongyang Xu, Jiahang Miao, Emi Yumoto, Takao Yokota, Masashi Asahina, Masaaki Watahiki*, YUCCA9-mediated auxin biosynthesis and polar auxin transport synergistically regulate regeneration of root systems following root cutting, Plant and Cell Physiology, 2017, 58: 1710-1723. (Cover paper)

8. Dongyang Xu, Qing Nie, Wenyan Wang, Lei Shi, He Yan*, Characterization of a transferable bcrABC and cadAC genes-harboring plasmid in Listeria monocytogenes strain isolated from food products of animal origin, International Journal of Food Microbiology, 2016, 217: 117-122.

9. Dongyang Xu, Yanli Li, M. Shamim Hasan Zahid, Shinji Yamasaki, Lei Shi, Jianrong Li*, He Yan*, Benzalkonium chloride and heavy-metal tolerance in Listeria monocytogenes from retail foods, International Journal of Food Microbiology, 2014, 190: 24-30.

10. Dongyang Xu, Yan Deng, Rongdong Fan, Lei Shi, Jianshan Bai*, He Yan*, Coresistance to benzalkonium chloride disinfectant and heavy metal ions in Listeria monocytogenes and Listeria innocua swine isolates from China, Foodborne Pathogens and Disease, 2019, 16: 696-703.

11. Yang Zhang^#, Dongyang Xu^#, Lei Shi, Rujian Cai, Chunling Li, He Yan*, Association between agar type, virulence factors, biofilm formation and antibiotic resistance of Staphylococcus aureus isolates from pork, Frontiers in Microbiology, 2018, 9: 1876. (Co-first author)

12. Yue Chen^#, Fei Qi^#*, Fan Gao, Huifen Cao, Dongyang Xu, Kourosh Salehi-Ashtiani and Philipp Kapranov*, Hovlinc is a recently evolved class of ribozyme found in human lncRNA, Nature Chemical Biology, 2021, 17: 601-607.

13. Huifen Cao^#, Lorena Salazar-Garcia^#, Fan Gao, Thor Wahlestedt, Chunlin Wu, Xueer Han, Ye Cai, Dongyang Xu, Fang Wang, Lu Tang, Natalie Ricciardi, Dingding Cai, Huifang Wang, Mario P.S. Chin, James A. Timmons, Claes Wahlestedt*, Philipp Kapranov*, Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells, Nature Communications, 2019, 10: 5799.

14. Fang Wang^#, Huifen Cao^#, Qiu Xia^#, Ziheng Liu, Ming Wang, Fan Gao, Dongyang Xu, Bolin Deng, Yong Diao, Philipp Kapranov*, Lessons from discovery of true ADAR RNA editing sites in a human cell line, BMC Biology, 2023, 21: 160.

15. Huifen Cao, Yufei Zhang, Ye Cai, Lu Tang, Fan Gao, Dongyang Xu, Philipp Kapranov*, Hotspots of single-strand DNA "breakome" are enriched at transcriptional start sites of genes, Frontiers in Molecular Biosciences, 2022, 9: 895795.

16. He Yan, Dongyang Xu, Hecheng Meng, Lei Shi, Lin Li*, Food poisoning by clenbuterol in China, Quality Assurance and Safety of Crops & Foods, 2014, 7: 27-35.

-授权发明专利

一种检测DNA中的单链断裂的方法，ZL 201910837092.1，2022，排名第5。